Pages

Dualsystems-Biotech-Ligand-receptor-binding

Ligand-receptor binding

Dualsystems-Biotech-Ligand-receptor-binding

Ligand-Receptor identification on living cells – The new LRC platforms


We offer a novel service Ligand-receptor capture LRC-TriCEPS™ to identify the unknown targets / off-targets / receptors of your ligand on the living cells. The LRC-TriCEPS™crosslinker technology invented by Dr. Andreas Frei and Prof. Bernd Wollscheid from the ETH Zurich who published the technology in Nature Biotechnology (Frei et al.(2012) Nature Biotechnology 30:997-1001) has now been further developed by Prof. Bernd Wollscheid and Dualsystems Biotech AG. The next generation of TriCEPS™ is now available to Dualsystems Biotech customers.

Dualsystems Biotech is a service provider for custom proteomics for industry and academia. We are a biotech company from Schlieren near by Zurich, specialized in target deconvolution and elucidating protein-protein interaction in the living cells especially at the cell membrane.


For more details about ligand and receptor look on our website Dualsystems.com


Orphan ligands:

  • Small molecules
  • Peptide ligands
  • Extracellular proteins
  • Antibodies
  • Engineered affinity binders
  • Viruses

Principle of LRC-TriCEPS™ Technology

How do the LRC platforms work? Here a short video explaining the technology


LRC-TriCEPS is a fast and sensitive approach to discover cell surface receptors for your ligand of interest:

  • Target identification on living cells
  • >80% coverage of the cell surfaceome
  • Proven to work in cells from humans, mammalians, insects, only limitation targets have to be N-, C- or O glycosylated
  • Target identification on cell lines, primary cells, tissue, but also in cell lysates
  • Results within 4-7 weeks (depending on the cells used)
  • Fee for Service model

Original publications

Contact us

The next generation of LRC-TriCEPS™-based ligand-receptor capture technology is now available.
Interested?

+41 44 738 50 00 or

Please contact us for more information

4 + 0 = ?

More Services information about Dualsystems Biotech